HER2-CDH1 Interaction via Wnt/B-Catenin Is Associated with Patients' Survival in HER2-Positive Metastatic Gastric AdenocarcinomaĪuthors: V De Re, L Alessandri, G Brisotto, L Caggiari, M De Zorzi, M Casarotto, G Miolo, F Puglisi, SK Garattini, S Lonardi, R Cannizzaro, V Canzonieri, M Fassan, A Steffan Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer ProgressionĪuthors: L Yu, M Toriseva, S Afshan, M Cangiano, V Fey, A Erickson, H Seikkula, K Alanen, P Taimen, O Ettala, M Nurmi, PJ Boström, M Kallajoki, J Tuomela, T Mirtti, IJ Beumer, M Nees, P HärkönenĮpithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoidsĪuthors: K Uehara, M Koyanagi-A, T Koide, T Itoh, T Aoi Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancerĪuthors: SH Gao, GZ Wang, LP Wang, L Feng, YC Zhou, XJ Yu, F Liang, FY Yang, Z Wang, BB Sun, D Wang, LJ Liang, DW Xie, S Zhao, HP Feng, X Li, KK Li, TS Tang, YC Huang, SQ Wang, GB Zhou International Journal of Molecular Sciences, 2022 23(3). The Kaohsiung journal of medical sciences, 2022 0(0).Ĭonversion of Human Fibroblasts into Induced Neural Stem Cells by Small MoleculesĪuthors: D Liu, G Rychkov, P Hurtado, HY Luo, T Zhang, L Bobrovskay, XF Zhou
#Rejection region calculator f tv#
Biological activities ascribed to EGF include epithelial development, angiogenesis, inhibition of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture.ĬHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicityĪuthors: D Bernareggi, Q Xie, BC Prager, J Yun, LS Cruz, TV Pham, W Kim, X Lee, M Coffey, C Zalfa, P Azmoon, H Zhu, P Tamayo, JN Rich, DS KaufmanĬERS6-AS1 contributes to the malignant phenotypes of colorectal cancer cells by interacting with miR-15b-5p to regulate SPTBN2Īuthors: SY Zhao, Z Wang, XB Wu, S Zhang, Q Chen, DD Wang, QF Tan Dimerization results in autophosphorylation of the receptor at specific tyrosine residues to create docking sites for a variety of signaling molecules (5, 8). EGF binds ErbB1 and depending on the context, induces the formation of homodimers or heterodimers containing ErbB2. These receptors undergo a complex pattern of ligand-induced homo- or hetero-dimerization to transduce EGF family signals (6, 7). EGF binding induces dimerization of the EGF receptor resulting in activation of the protein tyrosine kinase signaling pathway. Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members (5). EGF is a high affinity ligand of the EGF receptor (ErbB). Physiologically, EGF is found in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid (4). EGF is well conserved across mammals with mature human EGF 70% identical to mature mouse and rat EGF. However, the mature protein is much smaller, only 53 aa, and is generated by proteolytic cleavage of the EGF domain proximal to the transmembrane region (3).
#Rejection region calculator f full#
The full length EGF protein is 1207 amino acids (aa) (EGF precursor) containing nine EGF domains and nine LDLR class B repeats. The mature proteins are released from the cell surface by regulated proteolysis (1).
All EGF family members are synthesized as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. These disulfide bonds are essential for proper protein conformation and receptor binding. Members of The EGF family are characterized by a shared structural motif, the EGF‑like domain, which contains three intramolecular disulfide bonds that are formed by six similarly spaced, conserved cysteine residues (2). EGF is the founding member of the EGF family that also includes TGF-alpha, amphiregulin (AR), betacellulin (BTC), epiregulin (EPR), heparin‑binding EGF‑like growth factor (HB‑EGF), epigen, and the neuregulins (NRG)-1 through -6 (1). Epidermal growth factor (EGF) is a small, potent growth factor capable of inducing cell proliferation, differentiation, and survival.
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